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Review


doi: 10.1007/s00774-022-01375-x.


Online ahead of print.

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Review

Yuan-Wei Zhang et al.


J Bone Miner Metab.


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Abstract

Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel “organ transplantation” technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut-bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.


Keywords:

Fecal microbiota transplantation; Gut microbiota; Osteoporosis; The elderly.

References

    1. Reid IR (2020) A broader strategy for osteoporosis interventions. Nat Rev Endocrinol 16:333–339. https://doi.org/10.1038/s41574-020-0339-7

      –

      DOI

      –

      PubMed

    1. Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P (2018) Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet 391:230–240. https://doi.org/10.1016/s0140-6736(17)32137-2

      –

      DOI

      –

      PubMed

    1. Zhuang HF, Wang PW, Li YZ, Lin JK, Yao XD, Xu H (2020) Analysis of related factors of brittle hip fracture in postmenopausal women with osteoporosis. Orthop Surg 12:194–198. https://doi.org/10.1111/os.12605

      –

      DOI

      –

      PubMed

      –

      PMC

    1. Chawla A, Kwek EBK (2019) Fractures in patients with osteopetrosis, insights from a single institution. Int Orthop 43:1297–1302. https://doi.org/10.1007/s00264-018-4167-5

      –

      DOI

      –

      PubMed

    1. Zhang YW, Lu PP, Li YJ, Dai GC, Chen MH, Zhao YK, Cao MM, Rui YF (2021) Prevalence, characteristics, and associated risk factors of the elderly with hip fractures: a cross-sectional analysis of NHANES 2005–2010. Clin Interv Aging 16:177–185. https://doi.org/10.2147/cia.S291071

      –

      DOI

      –

      PubMed

      –

      PMC